British Air Force Typhoon FGR4s have operated alongside French warplanes in a combined operation on an hidden munitions depot in Syria operated by the IS group, per a report from the British defence ministry.
The facility, located using reconnaissance, was believed to be containing munitions and bombs, the statement said, and was located in mountainous terrain just above the ancient city of Palmyra in the heart of Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to hit a series of entry passages down to the site... initial indications indicate the objective was successfully hit," the MoD said.
There was no indication of any civilian impact in the strike on Saturday evening and each participating jet returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were supported by a Voyager tanker plane.
The Islamic State group - also known as the so-called Islamic State - established extremist governance over significant areas in Syria and Iraq until 2019.
"This operation underscores the UK's leading role, and determination to work closely with allied nations, to eradicate any re-emergence of IS and their harmful and extremist ideologies in the region," Britain's Defence Chief John Healey said.
UK warplanes have carried out patrols over Syrian airspace to "forestall any efforts to regroup" of IS following its defeat at the climactic battle in Baghuz in the year 2019, the MoD reported.
"I want to thank every member of British forces who took part in this mission for their expertise and their valour," he added. "Including them were thousands of British troops stationed over the holidays. This action, to remove terrorist threats who threaten our way of life, highlights how our armed forces are always on standby, continuously, protecting the UK at home and influential overseas."
Last December, the US military carried out what it termed a "large-scale strike" against Islamic State objectives in Syria, after an attack resulted in the deaths of two US troops and a civilian interpreter in Palmyra.
The United Nations reports Daesh still has between 5,000 and 7,000 fighters in Syria and Iraq.
